Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics
نویسندگان
چکیده
منابع مشابه
Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics
CONTEXT In a previous work, we have shown that penalized regression approaches can allow many genetic variants to be incorporated into sophisticated pharmacokinetic (PK) models in a way that is both computationally and statistically efficient. The phenotypes were the individual model parameter estimates, obtained a posteriori of the model fit and known to be sensitive to the study design. OBJ...
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چکیده ندارد.
Association screening of common and rare genetic variants by penalized regression
MOTIVATION This article extends our recent research on penalized estimation methods in genome-wide association studies to the realm of rare variants. RESULTS The new strategy is tested on both simulated and real data. Our findings on breast cancer data replicate previous results and shed light on variant effects within genes. AVAILABILITY Rare variant discovery by group penalized regression...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2015
ISSN: 1744-6872
DOI: 10.1097/fpc.0000000000000127